It is the first EU member state to secure such access since the formal lifting of a 15 year old ban on EU beef by the US in March last year.
The ban had been imposed over fears of BSE.
Irish Minister for Agriculture, Food and the Marine, Simon Coveney, said today's announcement was the “culmination of two years of intensive work” between the Irish Department of Agriculture and US officials.
Securing such access was a "huge prize" for the Irish beef sector, he added, given the size of the US market and the existing demand there for premium, grass-fed beef.
Irish authorities have to approve individual beef plants to export to the US, based on criteria agreed with their US counterparts.
The major increase in US beef prices, up by €1 per kg in the last year and now at €4.70 to €4.80 ($5.72) per kg, present a real opportunity for Irish grass-based beef exports, said Irish Farmers Association (IFA) President, Eddie Downey, when commenting on the development.